A good friend of mine has got me into watching the Show Dead Like Me. The main character is killed by a falling toilet seat and thus is given the nick name Toilet Seat for her afterlife. This to me is damn funny. "Oh, hey Toilet Seat. How's it going?" Here's an imaginary conversation between Bob Loblaw and Toilet Seat.
Loblaw: The name's Bob, Bob Loblaw. I'm a lawyer.
Seat: Really...I wouldn't have guessed.
Loblaw: Say, what's your name?
Seat: George but people call me Toilet Seat.
Loblaw: People call you Toilet Seat?
Seat: It's better than Bob Blahblah.
Loblaw: Huh, wait...HEY!
Other crazy nick names I've encountered:
'Rabi' (This is for an Agnostic Person.)
'Porno George'
'Cheese'
'Mince Meat'
'Fatty'
'Turtle'
'Sloth'
'Knuckles Dakota' (One of my favorite.)
'Screaming Itch'
'Kimberly The Pink Power Ranger' (This was for a guy.)
Top two favorite thanks to Mr. Reid:
'Meat Box'
'Beef Brick'
YamFu